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Image Search Results
Journal: Neuropsychiatric Disease and Treatment
Article Title:
Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats
doi: 10.2147/ndt.s199371
Figure Lengend Snippet: Figure 1 Simvastatin ameliorates t-PA-induced blood MMP-9/TIMP-1 ratio imbalance. Rats were pretreated with SIM (60 mg/kg/d) for the SIM+ group or water for the SIM- group for two weeks, then rats were received t-PA (10 mg/kg) for the t-PA+ group or normal saline for the t-PA- group 3 hrs after operation. Blood samples were collected via abdominal aorta puncture before sacrificed. (A) ELISA analysis of MMP-9 and TIMP-1 protein expression. (B) Real-time PCR analysis of MMP-9 and TIMP-1 mRNA levels. (C) The blood MMP-9/TIMP-1 protein ratio. (D) The blood MMP-9/TIMP-1 mRNA ratio. Bars express the mean ± SD of duplicates (n=6). **p<0.01 t-PA alone versus t-PA plus SIM; &&p<0.01 t-PA alone versus t-PA-/SIM-; ##p<0.01 versus sham group. Abbreviation: SIM, simvastatin.
Article Snippet: The
Techniques: Saline, Enzyme-linked Immunosorbent Assay, Expressing, Real-time Polymerase Chain Reaction